Women: Scarlett Johannson, Kate Beckinsale, Mary Louise Parker, Mary Elizabeth Winstead (Ramona Flowers in Scott Pilgrim), Jessica Alba (who I talked to on chatroulette for half an hour a while back, she's a lot of fun), Evangeline Lily, and definitely Amanda Palmer (and not just because she's dating Neil Gaiman)
Women I am glad no one has listed: any of the Kardashians, Maggie Gyllenhaal, and Sarah Palin.
There would be a handful more, but I'm still waking up and only partially sober.
Man crushes - Chris Hemsworth (Thor), Josh Holloway (Sawyer from Lost), Ian Somerhalder (Boone from Lost), and Timothy Olyphant. Ryan Reynolds is off the list because he's slept with Sandra Bullock on more than one occasion and she's hideous.
Oh, and I've got this theory that every human on the planet would fuck Sean Connery.