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hormone shifts and hormone treatment man-- yes- and variances in the brain, yes but man- that thread would be exhausting..haha
its easier if you take genitals out of the equation and just remember the brain is the largest sexual organ in the body- but given that most of us don't have fMRI built into our eyes (thatd be awesome) we have to categorize it by genitals and self sexual identification.
I've always looked at gender as being strictly physical, and not of emotional or orientation. Reason for viewing it as such is because there are significant physiological differences between men and women when it comes to medical conditions and treatment. For example, heart attack symptoms can be different between men and women. Or, abdominal pain for many different reasons. Also, typically, males are stronger than females.
Thus why I think cross dressing, and gender changes creates many more complications than what most wouldn't even consider. Please note, this doesn't mean I disagree with them. Just stating it strictly from a medical/scientific perspective is all.