EDIT
If you mean addiction by meaning, "the brain gets a bunch of 'feel-good hormones' if you do X action but you do it so much that it starts to overshadow your life" or "if you don't do X action, you'll feel really bad because of withdrawals" (this is more dependency though) then I guess? I don't see it being impossible. People get addicted to food and caffeine the same way.
People's brains are wired differently, which is why you have people that are prone to addictions than others. Some people have what some call, "addictive personalities" (still rooted in their neurology) and I think that's where the "marijuana is a gateway drug" myth came from. Marijuana itself doesn't make you seek out other drugs because you've open a floodgate of narcotics. Some people may get bored with marijuana and want to try more things, but it's more likely these people's brains are wired to seek out the "other things." Some people smoke or do drugs and always relapse or "can't" seem to quit. Others may try it once and think, "yeah, I'm not feeling it. I don't want to do this anymore." That's not saying you guys should smoke and test out your brain lol. They're still highly addictive and I don't know the percentage of "non-addicted" users. Point is, different neurophysiology, different paths.
Also, addiction isn't opiate-exclusive, opiate-related addictions is just one of the deadliest or perhaps the most publicized.
semi nerd alert that's probably unrelated:
Gambling addicts have a very low amount of dopamine that making a win barely makes it to their base dopamine level (and it's the only thing that does) OR they risk/reward factor is all boggled. Normal people may weigh risks or reward and logically choose which one is worth it. With these types of addicts, they see reward and their dopamine just skyrockets, making them make pretty dumb choices.